#16: Julia Roberts and Nick Nolte
The 1994 rom-com I Love Trouble featured Julia Roberts and Nick Nolte as characters who find romance while solving a mystery together. But behind the scenes, Roberts and Nolte reportedly couldn’t stand each other, going out of their way to make the set uncomfortable for everyone involved.

Tensions escalated to the point where they refused to share the screen, forcing the crew to use stand-ins to create the illusion they were filming together. However, when it came time for a kissing scene, there was no way around it—they had to face each other and film the kiss, setting aside their differences, if only briefly.